One post tagged with "cram"

Whole Genome Sequencing (WGS) projects generate massive amounts of data. While analysis costs are significant, storage costs often become the dominant expense over time. The key challenge: you need to preserve raw data and alignments for potential re-analysis with new tools, but you can't afford unlimited storage. This blog post explores how CRAM format provides a solution, achieving 45% storage savings compared to BAM while maintaining full lossless compression and re-alignment capability. Therefore, on the new version, nf-germline-short-read-variant-calling supports cram file for better storage cost and re-analysis.